5 Essential Elements For cees dekker
5 Essential Elements For cees dekker
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‘Indeed, that is about appropriate. I search for a physical knowledge of Organic systems within a base-up way. I think you could potentially distinguish three traces of investigate in my group in the intervening time. The initial problems chromosome composition: How can you have a metre-extensive DNA polymer folded and organised in such a microscopic cell? We now have made visualisation methods that let us to check how, as an example, SMC proteins loop DNA (movie on Youtube) so that you can Develop up chromosomes.
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To be a human being, I possess the biblical assignment to check out and use all the things in creation for the advantage of my neighbour. I tend not to working experience any conflict in between faith and science. On the contrary, my religion stimulates me to try and do science, to generally be open up-minded on this planet.’
Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design and style in 2005. (nl)
SMC complexes can go Actual physical roadblocks bigger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
Duration Charge of specific carbon nanotubes by nanostructuring Together with the scanning tunneling microscope
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
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Dekker started out his research on one carbon nanotubes in 1993 when he create a brand new line of research to study electrical transportation via single organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was reached inside a collaboration While using the group of Nobel laureate Richard Smalley. STM and nanolithography techniques have been used to display that these nanotubes are quantum wires at the single-molecule stage, with excellent Actual physical Qualities.
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with research from experiments of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. More not long ago his analysis has centered on learning chromatin composition and cell division with microbes on chip, although he is also aiming to ultimately Create synthetic cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Trained as a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes inside the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His current research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a residing synthetic cell from lifeless molecules. Dekker is an elected member of the KNAW and fellow towards the APS as well as the IOP.
2008, initial ceesdekker observation of protein-coated DNA translocation by means of nanopores; settled the origin from the electrophoretic force on DNA in nanopores; found a significant velocity increase of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of sound in carbon nanotubes in liquid
2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes